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  2. Genetics 101
  3. Week 13-14
  4. Evolutionary Genetics and Integration of Knowledge
  5. Activity: Simulations – Using Hardy-Weinberg Simulator for Population Genetics

Activity: Simulations – Using Hardy-Weinberg Simulator for Population Genetics

Completion requirements
Opened: Tuesday, 20 May 2025, 12:00 AM
Due: Tuesday, 27 May 2025, 12:00 AM

Instructions:

  1. Tool Selection:
    Use a Hardy-Weinberg simulation tool (examples include: Biology Simulations - Hardy-Weinberg, Learn Genetics Simulator, PHET, or any online simulator).

  2. Initial Setup:

    • Start with a population under Hardy-Weinberg equilibrium assumptions:

      • Large population size

      • Random mating

      • No mutation

      • No migration

      • No selection

    • Set initial allele frequencies (e.g., A = 0.6, a = 0.4). Run the simulation for 5–10 generations and record the frequencies of AA, Aa, and aa genotypes.

  3. Apply Evolutionary Forces (Run 3 Scenarios):

    • Genetic Drift: Reduce population size drastically and observe fluctuations in allele frequencies.

    • Natural Selection: Apply selection against a genotype (e.g., aa) and observe how allele frequencies shift.

    • Migration: Simulate the introduction of individuals from a different population with different allele frequencies.

  4. Record & Analyze:

    • Take screenshots or note values from each generation.

    • Create a simple line graph (using Excel or online chart tools) showing changes in allele frequencies across generations for each scenario.

  5. Reflection Questions (Answer Briefly):

    • What conditions must be met for Hardy-Weinberg equilibrium to hold true?

    • How did each evolutionary force affect the allele frequencies?

    • Which scenario showed the most drastic change and why?

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